Syntheses and activities of some bactobolin derivatives.
نویسندگان
چکیده
Some derivatives of bactobolin were prepared from bactobolin by dehydration or substitution reactions through tris(dimethylamino)alkoxyphosphonium salt formation. A derivative with low toxicity, 6-deoxybactobolin, showed moderate activity against Gram-positive and Gram-negative bacteria including methicillin-resistant Staphylococcus aureus.
منابع مشابه
Synthesis and activities of bactobolin derivatives having new functionality at C-3.
Some derivatives of bactobolin were prepared from bactobolin (1) by transformation of the dichloromethyl group at C-3 to the hydroxymethyl, carboxylic acid, methanesulfonyloxymethyl and aldehydeoxime groups. The derivatives proved to be less active than the parent antibiotic 1 against bacteria as well as cytotoxicity, indicating that the functionality at C-3 considerably influences the biologic...
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عنوان ژورنال:
- The Journal of antibiotics
دوره 45 5 شماره
صفحات -
تاریخ انتشار 1992